Benefits and risks of sugammadex

CC This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Anesthesiologists daily use a range of drugs, including intravenous anesthetics, neuromuscular-blocking drugs and their antagonists, opioids, and local anesthetics. Antagonists of neuromuscular-blocking drugs are used to reverse the action of neuromuscular-blocking drugs. However, rarely paradoxical muscle weakness [1,2], nausea, vomiting [3], bradyarrhythmias [4,5], and bronchoconstriction [6,7] occur with acetylcholines-terase inhibitors. Sugammadex is a recently introduced antagonist of neuro-muscular-blocking drugs. It binds and inactivates neuromuscu-lar-blocking agents, particularly rocuronium and vecuronium. Complex formation between sugammadex and rocuronium or vecuronium results in the rapid reversal of neuromuscular blockade compared to anticholinesterase drugs [8]. In clinical practice and during an unexpectedly difficult airway (cannot intubate, cannot ventilate situation), a rocuronium neuromus-cular blockade can be immediately reversed using sugammadex to restore spontaneous ventilation [9]. This is probably the most significant benefit of sugammadex. The ability of sugammadex to reverse rocuronium-induced neuromuscular blockade is not influenced by the choice of anesthetic (e.g., propofol versus sevoflurane) [10,11]. Therefore, when using sugammadex as the antagonist of neuromuscular-blocking drugs, there is a small risk of incomplete neuromuscular recovery or the reoccurrence of neuromuscular blockade following surgery. No dose adjustments are required in older patients [12]. When using antagonists of neuromuscular-blocking drugs, anticholinesterase drugs and anticholinergics (glycopyrrolate and atropine) are coad-ministered to reduce the cholinergic action of anticholinesterase drugs. In this particular treatment, a side effect is dry mouth. Some patients complain of dry mouth and a gritty taste after general anesthesia and surgery. However, should we select su-gammadex as the antagonist of neuromuscular-blocking drugs, we could avoid these problems. Although sugammadex has some benefits, it also has several side effects. Hypersensitivity to sugammadex is the major concern. However, hypersensitivity reactions rarely occur. In patients with known sugammadex hypersensitivity, it is contra-indicated. Other reported side effects include coughing, movement of a limb or the body, parosmia (abnormal sense of smell), and elevated urine levels of N-acetyl-glucosaminidase [13]. Theoretically , sugammadex can bind to endogenous and pharmaceutical molecules other than steroidal neuromuscular-blocking drugs, therefore reducing the efficacy of these molecules. When sugammadex has a very high affinity for another molecule, this molecule may displace rocuronium or vecuronium from the complex with sugammadex, resulting in the reoccurrence of neuromuscular blockade [14]. Sugammadex may interact with …